What is the Meaning of Inflammatory Markers?

Inflammatory markers are quantifiable biochemical indicators found in the blood that reflect the presence and intensity of systemic inflammation within the body. These molecules, which include high-sensitivity C-reactive protein (hs-CRP), fibrinogen, and various cytokines, are integral to the body's immune response to injury or infection. Persistently elevated inflammatory markers, even at low levels, are clinically associated with an increased risk of chronic diseases, including cardiovascular disease and metabolic dysfunction, and often signal a state of chronic cellular stress.

What is the Origin of Inflammatory Markers?

The concept of measuring these markers stems from the field of immunology and pathology, where acute phase reactants were first identified as proteins whose concentration changes significantly in response to inflammation. The modern clinical use of "inflammatory markers" extends beyond acute infection to assess the low-grade, chronic inflammation that underpins many age-related and lifestyle-driven diseases. This tracking provides a tangible link between immune status and long-term health.

What is the Mechanism of Inflammatory Markers?

The mechanism involves the release of pro-inflammatory cytokines, such as IL-6 and TNF-alpha, primarily from immune cells in response to tissue damage or metabolic stress. These cytokines then travel to the liver, stimulating the synthesis and secretion of acute-phase proteins like C-reactive protein. Hormonal imbalances, such as high cortisol or insulin resistance, can also promote a pro-inflammatory state, creating a vicious cycle where inflammation further disrupts endocrine signaling and accelerates cellular aging.

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