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Inflammatory Cytokine Signalling

Meaning

Inflammatory cytokine signaling describes the complex, intercellular communication network mediated by small protein messengers, known as cytokines, that regulate the body’s inflammatory and immune responses. These signaling molecules, such as Interleukin-6 and Tumor Necrosis Factor-alpha, are released by immune cells and adipocytes, acting on distant target cells to orchestrate a systemic inflammatory cascade. Chronic dysregulation of this signaling pathway, often termed low-grade systemic inflammation, is a key driver of age-related diseases and metabolic dysfunction. Modulating this signaling is a major therapeutic target in promoting overall health and longevity.