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Inflammatory Correlates SHBG

Meaning

Inflammatory Correlates SHBG refers to the well-documented clinical relationship where chronic, low-grade systemic inflammation significantly and dynamically influences the circulating concentration of Sex Hormone-Binding Globulin (SHBG). SHBG is a critical glycoprotein synthesized primarily by the liver that binds and transports sex hormones, predominantly testosterone and estradiol, thereby regulating their crucial bioavailability. Understanding this correlation is vital because inflammation, often driven by metabolic dysfunction, can drastically alter SHBG levels, consequently changing the effective free hormone concentration at the target tissue level.