What is the Origin of Inflammatory Cascade Suppression?

This term is derived from immunology and pathology, where "inflammatory cascade" describes the rapid, amplified sequence of biochemical events following tissue injury or infection. "Suppression" in this context refers to the clinical modulation of this response, moving away from chronic pathology toward resolution and repair.

What is the Mechanism of Inflammatory Cascade Suppression?

Suppression mechanisms involve the use of agents or interventions that stabilize cell membranes, inhibit the activation of key transcription factors like NF-kappaB, or block the production of pro-inflammatory cytokines, such as Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-α). These actions promote a shift toward anti-inflammatory signaling pathways and increase the production of specialized pro-resolving mediators (SPMs), which actively resolve the inflammatory process and facilitate tissue healing.

Inflammatory Cascade Suppression

Meaning

Inflammatory Cascade Suppression is the clinical and therapeutic strategy focused on actively inhibiting or moderating the sequential release and activation of pro-inflammatory mediators and signaling molecules in the body. Chronic, low-grade systemic inflammation, often termed ‘inflammaging,’ is a key driver of age-related disease and metabolic dysfunction. Successful suppression aims to restore immune balance, reduce tissue damage, and improve overall cellular function by dampening the hyper-responsive inflammatory state.