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Inflammatory Cascade Initiation

Meaning

Inflammatory Cascade Initiation refers to the precise molecular event that triggers the rapid, sequential activation of the body’s innate immune response to a perceived threat, such as tissue damage, infection, or chronic metabolic stress. This initiation involves the recognition of danger signals by pattern recognition receptors, leading to the activation of transcription factors like NF-κB and the subsequent massive release of pro-inflammatory cytokines and chemokines. In hormonal health, chronic, low-grade initiation of this cascade is a major driver of insulin resistance and HPA axis dysfunction.