What is the Origin of Inflammation Resolution Signaling?

This concept evolved from the traditional view of inflammation, which considered resolution as a passive event, to the modern understanding established by the discovery of pro-resolving mediators in the early 2000s. The term 'resolution signaling' highlights the existence of specific molecular commands that actively terminate the inflammatory cascade.

What is the Mechanism of Inflammation Resolution Signaling?

The mechanism is characterized by a "class switch" in eicosanoid production, moving from pro-inflammatory mediators like prostaglandins and leukotrienes to the synthesis of specialized pro-resolving mediators (SPMs) derived from omega-3 fatty acids. These SPMs act on specific G-protein coupled receptors to stop neutrophil infiltration, promote macrophage clearance of cellular debris, and stimulate tissue repair. Hormonal balance, particularly the modulation of cortisol, also plays a supportive role in this systemic resolution phase.

Inflammation Resolution Signaling

Meaning

Inflammation Resolution Signaling refers to the active, highly regulated biochemical pathways that initiate the cessation of the acute inflammatory response and promote tissue return to homeostasis. This process is not merely a passive dissipation of inflammatory mediators but an active, specialized program driven by endogenous lipid mediators known as resolvins, protectins, and maresins. Defective resolution signaling is a key pathophysiological feature in the transition from acute inflammation to chronic, low-grade systemic disease.