What is the Origin of Inflammation Resolution Science?

This field evolved from traditional immunology and pharmacology, which primarily focused on anti-inflammatory drugs that block inflammatory pathways. The shift to "resolution" began with the discovery of distinct biochemical pathways that actively shut down inflammation, notably the identification of lipoxins, resolvins, protectins, and maresins derived from omega-3 fatty acids. It represents a paradigm shift toward leveraging the body's intrinsic healing mechanisms.

What is the Mechanism of Inflammation Resolution Science?

The core mechanism involves the enzymatic conversion of polyunsaturated fatty acids, particularly EPA and DHA, into powerful pro-resolving lipid mediators (SPMs) by specific enzymes. These SPMs act on immune cells, instructing them to stop recruiting inflammatory cells, actively clear apoptotic cells and debris via efferocytosis, and initiate tissue repair. Optimal hormonal balance and micronutrient status are critical co-factors for the efficient function of these resolution pathways.

Inflammation Resolution Science

Meaning

Inflammation Resolution Science is a specialized area of study and clinical practice focused on actively promoting the natural, biological termination of the inflammatory response rather than merely suppressing its initiation. This science recognizes that chronic disease is often a failure of resolution, not just a presence of inflammation. The goal is to activate specific endogenous pro-resolving mediators, such as specialized pro-resolving mediators (SPMs), to safely clear inflammatory debris and restore tissue homeostasis without scarring or collateral damage.