What is the Origin of Inflammation Resolution Protocols?

The concept is derived from the field of resolution pharmacology, recognizing that inflammation is an active, not passive, process with distinct initiation and resolution phases. The term 'resolution protocols' signifies a structured, clinical approach to actively guide the body through the terminal phase of the inflammatory response. This paradigm shift emerged from the discovery of lipoxins, resolvins, and protectins as key endogenous mediators.

What is the Mechanism of Inflammation Resolution Protocols?

Resolution protocols operate by supplying precursors, such as specific omega-3 fatty acids, that are metabolized into SPMs like resolvins and protectins. These mediators act on immune cells, instructing them to stop recruiting inflammatory cells, to engulf and clear cellular debris (phagocytosis), and to initiate tissue repair programs. By enhancing these natural resolution pathways, the protocols prevent chronic, smoldering inflammation that underlies many age-related diseases.

Inflammation Resolution Protocols

Meaning

A systematic set of therapeutic and lifestyle strategies specifically designed to actively terminate the inflammatory response and promote the return of tissue to a state of homeostasis, rather than merely suppressing the initial inflammatory process. These protocols focus on activating endogenous biochemical pathways that generate specialized pro-resolving mediators (SPMs) to clear inflammatory debris and facilitate true healing. This is a crucial distinction from simple anti-inflammatory suppression.