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Inflammation Resolution Phase

Meaning

The Inflammation Resolution Phase is the active, genetically programmed biological process that orchestrates the orderly termination of acute inflammation and promotes tissue healing and a return to homeostatic balance. This is not a passive cessation of inflammation but an intricate, highly regulated phase involving the synthesis and release of specialized pro-resolving mediators (SPMs) derived from fatty acids. Clinically, a failure to successfully enter this phase is the primary mechanism by which acute inflammation transitions into a chronic, low-grade state.