What is the Origin of Inflammation Resolution Factors?

This term is a relatively recent development in immunology and lipid biochemistry, arising from the discovery that inflammation is not a passive process that simply fades away, but an active, tightly controlled process that requires specific 'resolution' signals. The origin is rooted in the identification of these specialized pro-resolving mediators (SPMs) and their distinct biochemical pathways. It reframed the understanding of the immune response from a simple fight to a complete cycle of defense and repair.

What is the Mechanism of Inflammation Resolution Factors?

Resolution factors are synthesized from omega-3 fatty acids and exert their function by binding to specific G-protein coupled receptors on immune cells, such as macrophages and neutrophils. Their action actively shuts down the production of pro-inflammatory cytokines and promotes the non-phlogistic clearance of apoptotic cells and inflammatory exudates. This programmed resolution is essential for preventing the transition from acute to chronic inflammatory states, which underlie many age-related diseases.

Inflammation Resolution Factors ∞ Area

Inflammation Resolution Factors

Meaning

A specific class of endogenous lipid mediators, including resolvins, protectins, and maresins, that actively promote the cessation of the inflammatory response and initiate the healing process. These factors represent the body’s active, programmed mechanisms for clearing cellular debris, restoring tissue integrity, and returning the site of injury to homeostasis. Clinically, enhancing their activity is a key strategy for managing chronic, low-grade inflammation.