What is the Origin of Inflammation Resolution Axis?

This concept emerged from advanced immunology and lipid mediator research, which shifted the understanding of inflammation from a simple, passive process of decay to an actively managed, cyclical event. The term 'Resolution Axis' highlights the necessity of a coordinated system for proper healing. Endocrine mediators, such as glucocorticoids, are integral components of this critical regulatory system.

What is the Mechanism of Inflammation Resolution Axis?

The resolution process is initiated by a metabolic switch in immune cells, leading to the synthesis of SPMs like resolvins, protectins, and maresins from omega-3 fatty acids. These mediators signal immune cells to stop recruitment, engulf cellular debris, and promote the regeneration of the damaged tissue matrix. Cortisol, released by the HPA axis, also plays a critical role by suppressing pro-inflammatory cytokine production, thereby facilitating the transition to the resolution phase.

Inflammation Resolution Axis ∞ Area

Inflammation Resolution Axis

Meaning

The complex, self-limiting biological pathway that actively coordinates the termination of the acute inflammatory response and promotes the return of tissue to a state of homeostasis. Unlike passive cessation of inflammation, this active resolution involves specialized pro-resolving mediators (SPMs) and hormonal signals that clear cellular debris and initiate tissue repair. A failure in this axis leads to chronic, low-grade inflammation, a key driver of age-related disease.