Inflammation Residue Management is a targeted clinical strategy focused on the resolution phase of inflammation, aiming to actively clear the lingering cellular debris, unresolved immune complexes, and fibrotic tissue that persist after an acute or chronic inflammatory episode. This process moves beyond merely suppressing pro-inflammatory mediators to ensure the complete restoration of tissue architecture and cellular function, which is vital for long-term hormonal balance. Unresolved residue can perpetuate a state of low-grade systemic stress.
Origin
This term is a modern refinement of immunology and pathology, shifting focus from the initiation and maintenance of inflammation to the active, controlled termination phase, a process mediated by specialized pro-resolving mediators (SPMs). The concept is gaining traction in longevity medicine, recognizing that the cumulative impact of poorly resolved inflammation is a primary driver of age-related endocrine decline and chronic disease.
Mechanism
The management protocol functions by utilizing specific nutritional factors, targeted peptides, and lifestyle interventions that promote the synthesis of SPMs, such as resolvins and protectins, derived from omega-3 fatty acids. These mediators actively signal macrophages to phagocytose (engulf) apoptotic cells and cellular waste, effectively clearing the “residue.” By accelerating this resolution, the systemic burden on the HPA axis is reduced, and chronic, low-grade inflammatory signaling, which can impair insulin and thyroid function, is extinguished.
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