Inflammation Regulation Science is the dedicated scientific and clinical discipline focused on understanding, precisely monitoring, and actively modulating the body’s complex inflammatory responses to maintain essential physiological homeostasis and prevent the progression of chronic disease. The ultimate goal is not to eliminate all inflammation, which is necessary for acute healing, but to rigorously resolve chronic, low-grade systemic inflammation, which is scientifically recognized as a key driver of biological aging and pervasive metabolic dysfunction. This field rigorously integrates immunology, endocrinology, and nutritional science for a holistic view.
Origin
This critical science emerged from the clinical and molecular realization that chronic, sterile inflammation, often termed “inflammaging,” underlies the pathology of virtually all age-related diseases, marking a significant shift in the clinical focus. The perspective moved from the traditional treatment of acute infection to the proactive management of persistent, detrimental immune dysregulation. This understanding highlights the clinical necessity of active, continuous regulation rather than passive acceptance of inflammatory states.
Mechanism
Regulation mechanistically involves identifying and meticulously mitigating the underlying sources of inflammatory signaling, which can include factors such as chronic gut dysbiosis, excessive visceral adiposity, or the accumulation of senescent cells. Targeted therapeutic agents are employed to promote the synthesis of pro-resolving lipid mediators. Crucially, the mechanism also includes optimizing hormonal balance, particularly the levels of cortisol and sex steroids, which collectively exert profound immunomodulatory effects to dampen the excessive production of pro-inflammatory cytokines like IL-6 and TNF-alpha.
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