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Inflammation Pathway Antagonism

Meaning

Inflammation pathway antagonism is a therapeutic strategy aimed at actively blocking or reducing the activity of specific molecular cascades that propagate chronic, low-grade systemic inflammation. This persistent inflammatory state, often termed “inflammaging,” is a primary driver of hormonal dysregulation and age-related chronic disease. The antagonism involves the use of targeted compounds or lifestyle modifications that inhibit key pro-inflammatory mediators, such as nuclear factor kappa B (NF-κB) or specific interleukins. By neutralizing these pathways, the body can restore hormonal sensitivity and improve overall metabolic homeostasis.