What is the Origin of Inflammation Neurotoxicity?

This concept merges immunology, neurology, and endocrinology, acknowledging the bidirectional communication of the neuroendocrine-immune axis. The term "Neurotoxicity" highlights the destructive impact on neural tissue, while "Inflammation" identifies the root cause. It is a key focus in understanding the pathogenesis of various neurodegenerative and psychiatric conditions.

What is the Mechanism of Inflammation Neurotoxicity?

Chronic inflammatory signals, such as elevated cytokines (e.g., interleukin-6, TNF-alpha), cross the blood-brain barrier or are produced by activated microglia within the brain. These inflammatory mediators directly interfere with neuronal function, increase oxidative stress, and can trigger apoptotic pathways. The resulting neurotoxicity disrupts the delicate hormonal and neurotransmitter balance necessary for optimal cognitive and emotional function.

Inflammation Neurotoxicity ∞ Area

Inflammation Neurotoxicity

Meaning

The detrimental process where chronic, low-grade systemic inflammation or localized neuroinflammation within the central nervous system causes damage or dysfunction to neurons and supporting glial cells. This neurotoxicity can impair synaptic plasticity, disrupt neurotransmitter balance, and contribute to cognitive decline and mood disorders. It represents a critical link between immune system activation and brain health.