The therapeutic or physiological process of regulating and balancing the body’s inflammatory response, aiming to reduce chronic, low-grade systemic inflammation without compromising the necessary acute immune response. This modulation is vital in hormonal health, as chronic inflammation disrupts endocrine signaling, particularly insulin sensitivity and the hypothalamic-pituitary axis.
Origin
The term combines ‘inflammation,’ derived from the Latin inflammare meaning to set on fire, with ‘modulation,’ meaning to regulate or adjust. The clinical relevance of modulation arose from the recognition that inflammation is not merely a disease symptom but a fundamental process that can be strategically influenced for better health outcomes.
Mechanism
Inflammation modulation functions by influencing the production and activity of pro-inflammatory and anti-inflammatory cytokines, chemokines, and eicosanoids, often through nutritional, lifestyle, or targeted pharmaceutical interventions. By restoring a healthy balance in this immune signaling, the body reduces oxidative stress and minimizes the antagonistic effects of chronic inflammation on cellular function and hormonal receptor sensitivity.
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