What is the Origin of Inflammation Longevity?

This term is a fusion of immunology and gerontology, arising from the scientific consensus that aging is characterized by a progressive, sterile increase in pro-inflammatory markers, even in the absence of acute infection. The root cause is often linked to accumulated cellular debris and chronic antigenic stress. It provides a concise framework for understanding a major physiological obstacle to extended vitality.

What is the Mechanism of Inflammation Longevity?

The negative impact on longevity is driven by the sustained activation of inflammatory pathways, such as the NF-κB signaling cascade, which leads to tissue damage, mitochondrial dysfunction, and the establishment of cellular senescence. This chronic inflammatory state disrupts hormonal signaling, accelerates telomere shortening, and contributes to the pathogenesis of conditions like cardiovascular disease and neurodegeneration. Interventions focus on resolving the underlying inflammatory triggers to dampen this detrimental biological feedback loop.

Inflammation Longevity ∞ Area

Inflammation Longevity

Meaning

Inflammation Longevity is a clinical paradigm that posits chronic, low-grade systemic inflammation, often termed “inflammaging,” as a primary determinant of healthspan and overall lifespan. The concept emphasizes that sustained control and reduction of this inflammatory burden are crucial for delaying the onset of age-related diseases and extending years of functional health. Successfully managing inflammation is viewed as a cornerstone strategy in any comprehensive longevity protocol.