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Inflammation Downregulation

Meaning

Inflammation Downregulation is the clinical and physiological process of actively reducing the systemic concentration of pro-inflammatory signaling molecules, such as cytokines and chemokines, and resolving chronic, low-grade inflammatory states. This is a crucial therapeutic objective in hormonal health, as chronic inflammation disrupts endocrine signaling, promotes insulin resistance, and accelerates cellular senescence. The goal is to shift the body’s immunological balance toward a state of resolution, tissue repair, and optimal metabolic function.