What is the Origin of Inflammation Dampening Compounds?

The development of these compounds is driven by geroscience research, which has identified chronic inflammation as a key hallmark and driver of the aging process and age-related pathology. The origin of therapeutic strategies is the identification of molecular pathways, such as NF-κB and mTOR, that link chronic immune activation to cellular senescence and tissue dysfunction.

What is the Mechanism of Inflammation Dampening Compounds?

These compounds operate by inhibiting key inflammatory signaling pathways, notably the IKK/NF-κB pathway, which acts as a master switch for the production of pro-inflammatory cytokines. They may also work by modulating nutrient-sensing pathways like mTOR, whose hyperfunction is linked to inflammation, or by boosting endogenous anti-inflammatory molecules. Examples include compounds that enhance NAD+ levels or directly inhibit specific cytokine activity, restoring cellular and systemic immune regulation.

Inflammation Dampening Compounds ∞ Area

Inflammation Dampening Compounds

Meaning

Inflammation Dampening Compounds are a class of therapeutic agents, including both pharmaceuticals and nutraceuticals, specifically employed to mitigate the chronic, low-grade systemic inflammation often termed “inflammaging.” These compounds are clinically used to restore immune balance, protect tissues from long-term inflammatory damage, and thereby slow the progression of numerous age-related diseases. The goal is to shift the body’s inflammatory status from a pro-aging state to a homeostatic, anti-aging state.