Specific, measurable biological indicators of systemic inflammation, such as C-reactive protein (CRP) or interleukins, whose levels are significantly influenced by and, in turn, influence the concentration and activity of circulating hormones. This clinical intersection is vital for assessing chronic disease risk and monitoring the efficacy of interventions aimed at balancing the endocrine and inflammatory systems. Hormonal dysregulation can drive inflammatory processes, while chronic inflammation can impair endocrine gland function.
Origin
This is a multidisciplinary term rooted in clinical pathology and endocrinology, reflecting the close clinical relationship between inflammatory states and endocrine function. The measurement of these biomarkers is a cornerstone of diagnostic and prognostic evaluation in modern medicine, providing insight into the body’s internal stress load. The concept is central to understanding the etiology of many chronic, age-related diseases.
Mechanism
Chronic inflammation can disrupt the hypothalamic-pituitary axes, notably the HPA and HPG axes, leading to altered cortisol and sex hormone production. Conversely, hormones like cortisol directly suppress the release of pro-inflammatory cytokines, such as Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-α). This complex feedback loop means that measuring biomarkers alongside hormone levels provides a more comprehensive picture of the body’s overall physiological stress and health status.
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