What is the Origin of Inflammation Biomarkers?

The concept stems from pathology and clinical chemistry, with the realization that certain molecules released during the inflammatory response could be reliably measured to assess disease activity. The acute phase reactants, like CRP, were among the first to be clinically utilized, tracing back to the mid-20th century. The modern emphasis is on identifying a panel of highly specific and sensitive biomarkers to differentiate acute from chronic, low-grade inflammation.

What is the Mechanism of Inflammation Biomarkers?

The synthesis of these biomarkers is typically triggered by pro-inflammatory cytokines, which are released by immune cells at the site of tissue damage or infection. For instance, Interleukin-6 (IL-6) stimulates hepatocytes in the liver to rapidly synthesize and release C-reactive protein into the circulation. Measuring the concentration of these molecules provides an indirect, yet precise, quantification of the underlying cellular and immunological stress, reflecting the body's attempt to mount a defense or repair mechanism.

Inflammation Biomarkers

Meaning

Quantifiable biological molecules found in blood, tissue, or other bodily fluids that serve as objective indicators of an active inflammatory process within the body. These markers reflect the systemic activation of the innate immune system in response to stress, injury, or chronic pathological states. Clinically relevant examples include C-reactive protein (CRP), interleukins (IL-6), and fibrinogen, which correlate with the degree of systemic cellular stress. Monitoring these biomarkers provides crucial diagnostic and prognostic information regarding disease risk and therapeutic efficacy.