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Inflammation-Aging Interface

Meaning

The Inflammation-Aging Interface describes the complex, bidirectional relationship between chronic, low-grade systemic inflammation and the progressive physiological decline associated with senescence. This interface is characterized by the persistent activation of innate immune pathways, a state termed “inflammaging,” which accelerates tissue damage and compromises cellular repair mechanisms. It is a critical nexus where metabolic dysregulation, hormonal decline, and age-related pathology converge. Understanding this interface is essential for developing interventions that target the root causes of age-related disease.