What is the Meaning of Inflammaging?

Inflammaging is a portmanteau term describing the chronic, low-grade, sterile, and systemic inflammation that characterizes the aging process, even in the absence of overt infection or autoimmune disease. This persistent inflammatory state is driven by the accumulation of senescent cells, mitochondrial dysfunction, and a dysregulated innate immune system, leading to the continuous, low-level release of pro-inflammatory cytokines like IL-6 and TNF-alpha. Inflammaging is a major driver of age-related diseases and directly contributes to endocrine resistance, particularly insulin and leptin resistance.

What is the Origin of Inflammaging?

The term "Inflammaging" was coined by Italian immunologist Claudio Franceschi in the early 2000s to concisely capture the inseparable link between the aging process and chronic inflammation, moving beyond the traditional view of aging as purely wear-and-tear. It is an etymological blend of "inflammation" and "aging," signifying a distinct, measurable biological phenotype of senescence. This concept has become foundational in longevity research and clinical anti-aging protocols.

What is the Mechanism of Inflammaging?

The mechanism involves the chronic activation of the innate immune system and the accumulation of senescent cells, which secrete a pro-inflammatory milieu known as the Senescence-Associated Secretory Phenotype (SASP). These circulating cytokines interfere with the signaling pathways of key metabolic hormones, causing receptor desensitization and driving metabolic dysregulation. For example, chronic inflammation impairs insulin signaling, contributing to hyperglycemia, and can disrupt the hypothalamic control of the HPT and HPG axes, accelerating age-related hormonal decline.

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