Question 1

What is the Meaning of Inflammaging Science?

Accepted Answer

Inflammaging Science is the interdisciplinary study of the chronic, low-grade, sterile, and systemic inflammation that characterizes the aging process, serving as a fundamental driver of age-related decline and pathology. This pervasive inflammatory state, distinct from acute infection, involves the persistent elevation of pro-inflammatory cytokines and chemokines, contributing to the pathogenesis of most non-communicable diseases of aging. Understanding and modulating inflammaging is a core objective of longevity and anti-aging medicine.

Question 2

What is the Origin of Inflammaging Science?

Accepted Answer

The term "Inflammaging" is a portmanteau coined by Professor Claudio Franceschi in the early 2000s, combining "inflammation" and "aging" to describe the inextricably linked phenomena. This concept shifted the paradigm from viewing aging as purely passive wear-and-tear to recognizing it as an active, biologically regulated process involving chronic immune system activation. It has since become a central tenet in gerontology and immunosenescence research.

Question 3

What is the Mechanism of Inflammaging Science?

Accepted Answer

The mechanism is complex, involving the accumulation of cellular debris and senescent cells—cells that have stopped dividing but remain metabolically active—which collectively form the Senescence-Associated Secretory Phenotype (SASP). These senescent cells continuously release pro-inflammatory molecules, including IL-6, IL-1β, and TNF-α, into the circulation. This chronic, low-level signaling compromises the function of the hypothalamic-pituitary-adrenal axis and reduces tissue sensitivity to key metabolic hormones like insulin, thereby accelerating the onset of metabolic and endocrine disorders.

Inflammaging Science

Meaning

Origin

Mechanism

Your Skin Reveals All

Provided by the clinical team
at 4Ever Young Miami Dadeland

-15% ∞ HRTIO15

Your protocol begins with a conversation.

Visit

Schedule Appointment

About

Med & Wellness

4Ever Young Miami Dadeland

Communication

+1 786-529-6686

Email Us

Opening Hours