What is the Origin of Inflammaging Reversal Strategies?

The term originates from the portmanteau "inflammaging," coined by scientists to describe the direct link between chronic inflammation and the aging process, combined with "reversal strategies" from clinical intervention planning. It acknowledges that aging is not merely a passive wear-and-tear process but an active, inflammatory one driven by immune system dysregulation and cellular senescence.

What is the Mechanism of Inflammaging Reversal Strategies?

Reversal strategies function by modulating key inflammatory signaling pathways, notably the NF-κB pathway, and reducing the overall inflammatory load. This is achieved through optimizing gut barrier function to minimize endotoxemia, clearing senescent cells that secrete pro-inflammatory SASP (Senescence-Associated Secretory Phenotype) factors, and correcting hormonal imbalances, such as high cortisol or low sex steroids, which can exacerbate inflammation. The goal is to shift the immune system from a pro-inflammatory state toward a balanced, regulatory one.

Inflammaging Reversal Strategies

Meaning

Inflammaging Reversal Strategies are targeted clinical and lifestyle interventions designed to counteract the state of chronic, low-grade, sterile inflammation that is a hallmark of biological aging. This persistent inflammatory state, termed ‘inflammaging,’ contributes significantly to the pathogenesis of most age-related diseases, including cardiovascular, neurodegenerative, and metabolic disorders. The strategies aim to dampen the excessive production of pro-inflammatory cytokines and restore immune-metabolic homeostasis.