What is the Origin of Inflammaging Reversal Protocols?

The term "inflammaging" is a portmanteau coined in the early 2000s, combining inflammation and aging, to describe the sterile, age-associated inflammatory phenotype. The reversal protocols represent the clinical application of longevity science to counteract this pathological process.

What is the Mechanism of Inflammaging Reversal Protocols?

These protocols operate by modulating key inflammatory pathways, such as the NF-κB and inflammasome complexes, through targeted nutritional compounds, lifestyle adjustments, and senolytic agents. By reducing the burden of senescent cells and dampening the chronic cytokine milieu, they improve cellular communication and enhance tissue sensitivity to endogenous hormones.

Inflammaging Reversal Protocols

Meaning

Comprehensive, multi-modal clinical strategies designed to mitigate and reverse the chronic, low-grade, systemic inflammation, known as inflammaging, that is a core driver of age-related functional decline and hormonal dysregulation. These protocols aim to restore immune homeostasis and cellular vitality.