What is the Origin of Inflammaging Resolution?

The term combines the clinical pathology of 'inflammaging'—a portmanteau of inflammation and aging—with the biological concept of 'resolution,' which refers to the active termination of the inflammatory response. The need for resolution stems from the recognition that chronic, unresolved inflammation is a primary driver of tissue damage and endocrine dysfunction. It emphasizes an active, rather than passive, return to immune homeostasis.

What is the Mechanism of Inflammaging Resolution?

Resolution is achieved by modulating key inflammatory transcription factors, such as NF-κB, and promoting the synthesis of specialized pro-resolving mediators derived from omega-3 fatty acids. Hormonal optimization plays a crucial role, as adequate levels of sex steroids and cortisol help maintain immune balance and suppress excessive cytokine release. The intervention works to clear senescent cells and reverse the age-associated shift toward a pro-inflammatory cellular phenotype.

Inflammaging Resolution ∞ Area

Inflammaging Resolution

Meaning

Inflammaging Resolution is the therapeutic process of actively reversing or significantly mitigating inflammaging, which is the chronic, sterile, low-grade systemic inflammation that characterizes biological aging and drives many age-related diseases. Resolution involves targeted interventions to downregulate pro-inflammatory pathways and upregulate the body’s natural anti-inflammatory and repair mechanisms. Achieving inflammaging resolution is a cornerstone of longevity medicine, aiming to restore youthful immune and metabolic function. This intervention is critical for extending healthspan.