Inflammaging reduction strategies are interventions designed to counteract the chronic, low-grade, systemic inflammation that accumulates with advancing age.
Context
This phenomenon occurs within the aging organism, affecting cellular function, immune system regulation, and contributing to the pathogenesis of numerous age-related diseases.
Significance
Addressing inflammaging is key to promoting healthspan, delaying the onset of chronic diseases, and maintaining functional capacity throughout later life.
Mechanism
These strategies typically focus on modulating inflammatory pathways, reducing oxidative stress, clearing senescent cells, and supporting cellular repair mechanisms.
Application
Practical approaches include dietary adjustments favoring anti-inflammatory foods, regular physical activity, stress management, and the judicious use of specific nutraceuticals or pharmaceuticals.
Metric
Monitoring involves tracking inflammatory biomarkers such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), alongside assessments of cellular senescence.
Risk
Certain interventions may inadvertently suppress necessary immune responses or interact with existing medical conditions, requiring careful clinical supervision.
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