Inflammaging Reduction is the therapeutic objective of actively decreasing the chronic, low-grade inflammatory state associated with the aging process. This systemic inflammation, often subclinical, contributes significantly to tissue damage, hormonal imbalance, and the pathogenesis of age-related conditions. Clinical strategies for reduction involve a multi-modal approach to decrease the burden of senescent cells and dampen the overactive innate immune response. Successfully achieving inflammaging reduction is a measurable outcome that supports extended healthspan and improved quality of life.
Origin
This term is a clinical application of the scientific concept of Inflammaging, which highlights the intertwined nature of inflammation and aging, first formally described in the early 21st century. The ‘reduction’ component emphasizes the actionable, intervention-based nature of modern longevity protocols, moving beyond passive observation of the aging phenotype. It draws upon research demonstrating that modulating inflammatory pathways can decelerate biological aging.
Mechanism
The core mechanism involves utilizing specific interventions, such as senolytics, targeted nutrition, and peptide modulators, to downregulate pro-inflammatory signaling cascades. These agents work to restore the balance between pro- and anti-inflammatory cytokines, reducing the persistent cellular stress that drives tissue deterioration. By mitigating the effects of the senescence-associated secretory phenotype (SASP), this reduction preserves mitochondrial function and maintains cellular resilience.
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