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Inflammaging Pathway Interruption

Meaning

Inflammaging Pathway Interruption refers to therapeutic strategies specifically designed to halt or significantly mitigate the chronic, low-grade, sterile inflammatory state that is a hallmark of biological aging. This intervention targets the persistent activation of pro-inflammatory signaling cascades, such as the NF-κB pathway and the inflammasome. Successful interruption aims to reduce the circulating levels of pro-inflammatory cytokines, including Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-α). Clinically, this approach seeks to slow the progression of age-related diseases and maintain optimal endocrine function, which is often compromised by chronic inflammation.