Inflammaging Mitigation is the targeted clinical and lifestyle strategy focused on reducing and systematically controlling the chronic, low-grade, sterile systemic inflammation that is a fundamental characteristic of the aging process. This pervasive, subclinical inflammatory state, often termed “inflammaging,” is a key, non-infectious driver of virtually all age-related diseases and functional decline, accelerating cellular senescence and tissue damage. Mitigation involves identifying, addressing, and neutralizing the diverse sources of this persistent inflammatory burden.
Origin
The term is a portmanteau combining “inflammation” and “aging,” first formally coined in the scientific literature of biogerontology to describe the fundamental role of chronic, persistent immune activation in the pathogenesis of aging. Its clinical application reflects the growing and critical understanding that managing this pervasive inflammatory state is as essential for long-term healthspan as managing traditional risk factors like blood pressure or cholesterol. This concept is central to modern preventative and anti-aging medicine.
Mechanism
The mechanism involves the systemic downregulation of pro-inflammatory cytokine production, such as Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF- α), and the restoration of the balance between pro- and anti-inflammatory signaling pathways. This is often achieved through optimizing hormonal status, as hormones like DHEA and the sex steroids possess significant immunomodulatory and anti-inflammatory effects, and by correcting underlying metabolic dysfunctions like insulin resistance, which acts as a chronic inflammatory fuel source. Reducing this persistent immune stress helps preserve tissue integrity and stem cell function.
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