What is the Origin of Inflammaging Mitigation Tactics?

The term is a portmanteau of "inflammation" and "aging," first coined to describe the persistent, sterile inflammatory state associated with advancing chronological age. "Mitigation Tactics" refers to the specific, actionable strategies used in clinical practice to lessen this detrimental biological process. The concept is central to geroscience, the study of the biological mechanisms of aging.

What is the Mechanism of Inflammaging Mitigation Tactics?

Tactics focus on addressing the root causes of inflammaging, including gut dysbiosis, visceral adiposity, and cellular debris accumulation. Nutritional interventions target the reduction of pro-inflammatory cytokines like IL-6 and TNF-alpha, while promoting the resolution of inflammation. Other strategies involve optimizing sleep, managing psychological stress, and utilizing compounds that activate anti-inflammatory pathways like the Nrf2 signaling cascade.

Inflammaging Mitigation Tactics ∞ Area

Inflammaging Mitigation Tactics

Meaning

Inflammaging Mitigation Tactics are a collection of strategic interventions designed to reduce and manage the state of chronic, low-grade, systemic inflammation that characterizes the aging process. This smoldering inflammation, often subclinical, drives cellular senescence, hormonal resistance, and tissue damage over time. Effective mitigation is paramount for extending healthspan and reducing the risk of age-related diseases.