What is the Origin of Inflammaging Mitigation Strategy?

The term "Inflammaging" is a portmanteau coined by gerontologists, combining inflammation and aging, to describe the sterile, age-related increase in pro-inflammatory markers. The "Mitigation Strategy" is the clinical response to this fundamental aging hallmark.

What is the Mechanism of Inflammaging Mitigation Strategy?

The strategy operates by suppressing the activation of the NF-κB pathway, a central regulator of inflammatory gene expression, and by promoting the clearance of senescent cells that secrete pro-inflammatory SASP (Senescence-Associated Secretory Phenotype) factors. Interventions often include targeted peptides, metabolic modulators, and specific anti-inflammatory nutraceuticals to restore immune homeostasis.

Inflammaging Mitigation Strategy ∞ Area

Inflammaging Mitigation Strategy

Meaning

A proactive, multi-faceted clinical plan designed to reduce and control the chronic, low-grade, systemic inflammation that characterizes the aging process, a phenomenon known as “inflammaging.” This strategy targets the underlying cellular drivers of inflammation, such as senescent cells and dysregulated immune responses. Effective mitigation is essential for preserving tissue function and extending healthspan.