What is the Origin of Inflammaging Mitigation Science?

The term "inflammaging" is a portmanteau coined by scientists, merging "inflammation" and "aging," to describe the specific inflammatory phenotype associated with senescence. The science of its mitigation is rooted in immunology, gerontology, and molecular biology, recognizing that chronic inflammation is not merely a consequence of aging but a primary driver. Clinical application of this science is a cornerstone of modern longevity medicine.

What is the Mechanism of Inflammaging Mitigation Science?

Mitigation strategies operate by modulating key inflammatory signaling pathways, notably the NF-κB pathway, and promoting the resolution of chronic inflammation. Interventions often include targeted nutraceuticals, specific dietary patterns, and lifestyle modifications designed to enhance the body's intrinsic anti-inflammatory and antioxidant defenses. The goal is to restore immune homeostasis and prevent the systemic damage caused by the persistent low-level inflammatory state.

Inflammaging Mitigation Science ∞ Area

Inflammaging Mitigation Science

Meaning

A specialized field of research and clinical practice focused on understanding, measuring, and counteracting “inflammaging,” which is the chronic, low-grade, sterile, systemic inflammation that characterizes the aging process. Mitigation strategies aim to reduce the persistent elevation of pro-inflammatory cytokines, such as IL-6 and TNF-alpha, which drive cellular senescence and organ system decline. Successful mitigation is essential for extending healthspan and reducing the risk of all major age-related diseases.