What is the Origin of Inflammaging Mechanism?

This term is a portmanteau, deliberately combining 'inflammation' and 'aging,' and was coined by gerontology researchers to precisely define the causal link between chronic immune activation and the trajectory of senescence. It places inflammation at the very core of the pathological processes associated with aging.

What is the Mechanism of Inflammaging Mechanism?

As individuals age, the accumulation of senescent cells, the expansion of dysfunctional visceral fat, and a gradual decline in immune system efficiency contribute to the persistent, low-level release of pro-inflammatory cytokines like Interleukin-6 and TNF-alpha. This continuous inflammatory signal disrupts cellular homeostasis, accelerates telomere shortening, and directly impairs insulin signaling and endothelial function. Modulating this chronic inflammatory state is a key strategy for mitigating age-related decline.

Inflammaging Mechanism ∞ Area

Inflammaging Mechanism

Meaning

The Inflammaging Mechanism describes the chronic, persistent, low-grade systemic inflammation that is recognized as a fundamental hallmark of the biological aging process and a primary driver of age-related diseases. This is not an acute immune response but a subtle, continuous elevation of pro-inflammatory markers that silently causes cumulative damage to tissues and organs over decades. Understanding this mechanism is crucial for developing targeted interventions aimed at extending healthspan and promoting longevity.