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Inflammaging Gut Connection

Meaning

The Inflammaging Gut Connection describes the critical, well-established bidirectional link between the health of the intestinal ecosystem and the state of inflammaging, which is the chronic, low-grade, sterile systemic inflammation that universally characterizes biological aging. This connection fundamentally posits that a compromised intestinal barrier function, often termed “leaky gut,” and microbial dysbiosis are potent, primary drivers of systemic inflammaging. Addressing and restoring the integrity of the gut is thus recognized as a foundational strategy for mitigating age-related chronic disease and associated hormonal decline.