What is the Origin of Inflammaging Control?

The term is a portmanteau of 'inflammation' and 'aging,' coined to describe this persistent, subclinical inflammatory burden characteristic of senescence. It acknowledges that immune system dysregulation accompanies chronological progression. This state is fundamentally different from acute inflammatory responses.

What is the Mechanism of Inflammaging Control?

Control involves downregulating pro-inflammatory cytokine production, often mediated by reducing visceral adiposity or optimizing gut microbiome balance. Certain hormone modulations can shift immune cell polarization away from a pro-inflammatory phenotype. Stabilizing cellular energy production also reduces oxidative stress, a major upstream activator of inflammatory cascades.

Inflammaging Control

Meaning

The clinical strategy focused on mitigating the chronic, low-grade, sterile inflammation that accumulates with age and contributes significantly to age-related disease and functional decline. Effectively controlling this systemic inflammatory state is paramount for extending healthspan. It represents a key target in longevity science.