Inflammaging Attenuation Science is the specialized field dedicated to identifying, measuring, and therapeutically mitigating the chronic, low-grade, systemic inflammation that underlies the aging process. This subclinical inflammation, termed ‘inflammaging,’ is a primary driver of age-related hormonal dysregulation, cellular senescence, and the development of chronic diseases. Attenuation science focuses on strategies that actively reduce the circulating levels of pro-inflammatory cytokines, such as interleukin-6 and tumor necrosis factor-alpha. Successful attenuation is a key vector for extending healthspan and optimizing endocrine function.
Origin
The term is a compound of ‘inflammaging,’ a portmanteau of inflammation and aging coined in the early 2000s, and ‘attenuation,’ derived from the Latin attenuare, meaning to make thin or less severe. This scientific discipline emerged from the realization that aging is not merely a passive decline but an active, inflammatory process. The science is rooted in immunology and endocrinology, recognizing the bidirectional relationship between the immune system and hormone signaling.
Mechanism
The mechanism of attenuation involves targeting the cellular sources of chronic inflammation, such as senescent cells and dysbiotic gut microbiota, and modulating key inflammatory signaling pathways like NF-kappaB. Clinically, this is achieved through precision nutrition, specific anti-inflammatory nutraceuticals, and lifestyle adjustments that enhance antioxidant defenses. By lowering the systemic inflammatory burden, the body can restore optimal cellular signaling and receptor sensitivity, which is critical for the healthy function of the entire endocrine cascade.
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