What is the Origin of Inflammaging Attenuation?

The term originates from the convergence of immunology and gerontology, specifically defining the persistent inflammatory phenotype seen in older organisms. Clinical application seeks to reverse this detrimental, age-associated baseline.

What is the Mechanism of Inflammaging Attenuation?

Attenuation mechanisms focus on suppressing key inflammatory mediators such as NF-κB signaling pathways or reducing the burden of senescent cells which secrete pro-inflammatory cytokines. Furthermore, optimizing anabolic hormones often indirectly reduces systemic inflammation by improving metabolic efficiency. This ultimately supports a healthier cellular microenvironment less prone to chronic pathology.

Inflammaging Attenuation ∞ Area

Inflammaging Attenuation

Meaning

Inflammaging Attenuation is the active therapeutic reduction of the chronic, low-grade, systemic inflammatory state that progressively develops with advancing chronological age. This persistent, non-resolving inflammation is a recognized hallmark of aging that drives numerous degenerative processes. Attenuation implies a deliberate clinical effort to suppress these pro-inflammatory signals. We target this chronic state because it compromises tissue function and hormonal signaling fidelity.