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Inflamm-Aging

Meaning

Inflamm-Aging is a clinical term describing the chronic, low-grade, sterile, and systemic inflammation that characterizes the aging process, even in the absence of overt infection. This persistent elevation of inflammatory biomarkers, such as C-reactive protein and pro-inflammatory cytokines, is a major driver of cellular senescence and age-related chronic diseases, including cardiovascular disease, neurodegeneration, and metabolic dysfunction. It represents a state of chronic immune system activation that erodes physiological reserve and accelerates the decline in hormonal function. Mitigating this smoldering inflammatory state is a central goal of anti-aging and longevity medicine.