Incretin pathway support refers to clinical or nutritional strategies designed to enhance the function of the body’s incretin hormones, primarily Glucagon-Like Peptide-1 (GLP-1) and Glucose-Dependent Insulinotropic Polypeptide (GIP), which are gut-derived peptides that regulate glucose homeostasis and appetite. This support aims to amplify the incretin effect, improving glucose-dependent insulin secretion from pancreatic beta cells and promoting a feeling of fullness. Optimizing this pathway is a core strategy in managing metabolic health, weight regulation, and mitigating the progression of insulin resistance.
Origin
The term originates from the discovery of the “incretin effect” in the mid-20th century, which established that oral glucose ingestion elicits a significantly greater insulin response than intravenous glucose, indicating a gut-mediated hormonal signal. The word ‘incretin’ is a portmanteau of intestine and secretion. ‘Pathway Support’ is a modern clinical phrase emphasizing the therapeutic goal of bolstering this natural physiological cascade for health and longevity benefits.
Mechanism
The mechanism of support involves either pharmacological agents, such as GLP-1 receptor agonists, or specific nutrient compositions that stimulate the L and K cells of the intestinal epithelium to increase the secretion of endogenous incretins. These peptides then travel via the circulation to target tissues: the pancreas, where they potentiate insulin release; the liver, where they suppress glucagon secretion; and the brain, where they modulate central appetite regulation. This multifaceted action effectively enhances glucose clearance and reduces caloric intake.
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