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In Vitro Release Testing

Meaning

In Vitro Release Testing (IVRT) is a standardized laboratory procedure performed outside of a living organism to quantitatively measure the rate and extent at which an active pharmaceutical ingredient is released from a semi-solid dosage form. This testing is crucial for quality control and the development of topical and transdermal hormone creams and gels. IVRT serves as a predictive tool for the drug’s bioavailability, providing critical data on how the hormone will become available for absorption into the systemic circulation. Consistent and reproducible release profiles are essential for ensuring predictable therapeutic outcomes.