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Immuno-Endocrine Axis

Meaning

The Immuno-Endocrine Axis describes the complex, integrated, and bidirectional communication network that seamlessly connects the body’s immune system with the endocrine system. This physiological axis represents a critical interface where circulating hormones and neuropeptides directly modulate the function and activity of immune cells, while immune-derived signaling molecules, such as cytokines, simultaneously influence the secretion and action of hormones. The harmonious balance of this axis is fundamental for maintaining overall systemic health, as chronic dysregulation can contribute to persistent inflammation, autoimmune disorders, and various endocrine pathologies. Clinically, understanding this crosstalk is essential for managing conditions where hormonal imbalance and immune dysfunction are intertwined.