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Immune System Robustness

Meaning

Immune System Robustness describes the capacity of the body’s defense mechanisms to mount an appropriate, effective, and rapidly resolved response to pathogenic challenges while simultaneously maintaining tolerance to self-antigens. This state is profoundly influenced by the neuroendocrine system, as hormones like cortisol, thyroid hormone, and sex steroids modulate the activity and differentiation of immune cells. Clinically, fostering robustness is key to preventing chronic inflammation, reducing susceptibility to infection, and supporting overall systemic resilience and longevity. This resilience ensures the immune system operates efficiently without becoming dysregulated.