Immune system peptides are a diverse group of small, biologically active protein fragments that serve as critical signaling molecules within the innate and adaptive immune responses, orchestrating defense against pathogens and regulating inflammation. This category includes cytokines, chemokines, and defensins, which are essential for cellular communication and the coordinated function of immune cells like T-cells and macrophages. Their balanced activity is vital for maintaining immunological tolerance and overall health.
Origin
The study of these molecules is central to immunology, evolving from the initial understanding of protein-based mediators of inflammation and immunity. The term Immune System Peptides specifically categorizes them by their functional role as regulators of immune cell activity and communication. The therapeutic application of these peptides represents a novel strategy for immunomodulation in clinical practice.
Mechanism
Immune system peptides primarily operate by binding to specific cell surface receptors on immune and non-immune cells, triggering intracellular signaling cascades that modulate gene expression related to inflammation, cell proliferation, and cell death. Chemokines, for instance, create a chemical gradient to direct the migration of immune cells to sites of infection or injury. The precise regulation of these peptide signals is crucial; dysregulation can lead to chronic inflammation or autoimmune conditions.
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