The targeted clinical effort to re-establish the body’s innate and adaptive capacity to detect and eliminate aberrant cells or pathogens before they establish disease. This involves bolstering the function of T-cells, NK cells, and appropriate cytokine profiles. We aim to restore innate protective vigilance.
Origin
Stemming from immunology, this concept is critical in longevity science where immune decline (immunosenescence) is a major factor in age-related morbidity. Restoration implies correcting deficits caused by chronic stress or endocrine imbalance.
Mechanism
Restoration often involves optimizing thymic output, modulating the balance between pro- and anti-inflammatory cytokines, and ensuring sufficient nutritional cofactors for lymphocyte proliferation. Crucially, balanced cortisol signaling prevents chronic immunosuppression, allowing immune cells to effectively patrol tissues for threats.
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