Immune Recalibration is a clinical concept signifying the process of restoring a balanced, appropriate functional state to a dysregulated immune system. The objective is to dampen chronic, systemic inflammation and re-establish immunological self-tolerance, moving the body away from chronic hyper-responsiveness or autoimmune tendencies. This recalibration is a vital strategy in managing autoimmune diseases and promoting longevity by mitigating immunosenescence.
Origin
This term functions as a clinical metaphor, combining “immune,” relating to the body’s defense system, with “recalibration,” implying the necessary fine-tuning of a sensitive biological instrument. It highlights the systemic goal of achieving a balanced, accurate immune response, rather than simple suppression.
Mechanism
The mechanism of recalibration involves targeted interventions designed to modulate key immune cell populations, particularly enhancing the function of T regulatory cells, and shifting the overall cytokine balance away from a pro-inflammatory profile. By identifying and addressing root cause triggers, such as gut dysbiosis or chronic viral load, the process aims to restore the appropriate Th1/Th2/Th17 balance and reduce the production of self-reactive antibodies, thereby normalizing immune surveillance.
Discontinuing hormone therapy prompts a systemic recalibration, causing transient but significant shifts in immune cell function and inflammatory responses.
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