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Immune-Mediated Resistance

Meaning

Immune-Mediated Resistance is a pathological state where the body’s immune system actively interferes with or neutralizes the biological activity of an administered therapeutic agent, often a protein or peptide hormone. This resistance typically manifests through the production of neutralizing antibodies that bind to the drug, rendering it ineffective and leading to a loss of therapeutic effect over time. This phenomenon is a significant clinical challenge in the field of endocrinology, particularly with replacement therapies involving exogenous hormones or peptides. Recognizing this resistance is essential for timely adjustment of the patient’s treatment plan.