Question 1

What is the Meaning of IL-17?

Accepted Answer

IL-17, or Interleukin-17, is a foundational pro-inflammatory cytokine, a type of signaling protein that plays a crucial role in both protective immunity against extracellular pathogens and the pathogenesis of chronic inflammatory and autoimmune diseases. It is primarily produced by a specialized subset of T helper cells known as Th17 cells, and its presence is a key marker of a robust inflammatory response. Dysregulation of IL-17 signaling is centrally implicated in conditions such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease.

Question 2

What is the Origin of IL-17?

Accepted Answer

Interleukin-17 was first identified in 1993, isolated from a rodent T-cell hybridoma, and was initially referred to as CTLA8. Its name, derived from the Latin inter- meaning "between" and leukos meaning "white" (referring to leukocytes), reflects its role as a chemical messenger communicating between immune cells. The subsequent discovery of the distinct Th17 cell lineage cemented IL-17's role as the signature cytokine of this powerful inflammatory pathway.

Question 3

What is the Mechanism of IL-17?

Accepted Answer

IL-17 mediates its effects by binding to the widely expressed IL-17 receptor complex (IL-17R) on various target cells, including epithelial cells, fibroblasts, and endothelial cells. Receptor activation triggers a signaling cascade that leads to the massive induction and release of other pro-inflammatory cytokines, chemokines, and matrix metalloproteinases. This molecular mechanism results in the recruitment of innate immune cells, particularly neutrophils, to the site of infection or inflammation, driving the acute phase response and subsequent tissue damage in chronic disease states.

IL-17

Meaning

Origin

Mechanism

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