Question 1

What is the Meaning of IGFALS?

Accepted Answer

IGFALS stands for Insulin-like Growth Factor Binding Protein, Acid Labile Subunit, a large serum protein that is a critical component of the ternary complex that transports Insulin-like Growth Factors (IGFs). This protein dramatically increases the half-life of IGF-I and IGF-II in the circulation, effectively acting as a reservoir and regulating their bioavailability to target tissues. Its presence is indispensable for the stable endocrine action of IGFs.

Question 2

What is the Origin of IGFALS?

Accepted Answer

The term derives from the biochemical characterization of the circulating IGF system, which identified a major, high-molecular-weight complex comprising IGF-I or IGF-II, IGF-Binding Protein-3 (IGFBP-3), and the Acid Labile Subunit (ALS). The gene encoding this protein is IGFALS, and its expression is known to be stimulated primarily by Growth Hormone (GH). This complex structure ensures that IGFs are protected from rapid degradation.

Question 3

What is the Mechanism of IGFALS?

Accepted Answer

IGFALS binds specifically to IGFBP-3 or IGFBP-5 only when those binding proteins are already complexed with an IGF molecule. This formation of the large, ternary complex prevents the rapid clearance of IGFs from the bloodstream, prolonging their action and ensuring systemic delivery. Defects in the IGFALS gene lead to significantly diminished circulating IGF-I and IGFBP-3 levels, resulting in growth impairment and demonstrating its crucial role in the GH/IGF axis.

IGFALS

Meaning

Origin

Mechanism

How Do Genetic Markers Influence Growth Hormone Sensitivity?

Provided by the clinical team
at 4Ever Young Miami Dadeland

-15% ∞ HRTIO15

Your protocol begins with a conversation.

Visit

Schedule Appointment

About

Med & Wellness

4Ever Young Miami Dadeland

Communication

+1 786-529-6686

Email Us

Opening Hours